CBG vs. CBD: Your Questions Answered

CBG vs. CBD: Your Questions Answered

Unlocking the secrets of the cannabis plant has been a captivating pursuit for scientists, researchers, and curious minds throughout history. With each revelation, this enigmatic plant has continued to surprise and intrigue, offering a plethora of compounds that hold the potential to revolutionize our understanding of health and medicine.

While CBD has undoubtedly taken center stage in recent years, the spotlight on CBG has been somewhat understated, yet its importance should not be overlooked. Today, we embark on a journey to unravel the similarities and differences between CBG and CBD, delving into their potential benefits and exploring the myriad of health and wellness applications they offer.

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What Is CBG? 

CBG, short for cannabigerol, is one of the many naturally occurring compounds found in the cannabis plant. It belongs to a class of compounds called cannabinoids, which are known for their interactions with the human body's endocannabinoid system. While CBG may not have garnered as much attention as its more famous counterpart, CBD, it has recently emerged as a subject of great interest among researchers and cannabis enthusiasts.

CBG is often referred to as the "mother cannabinoid" because it serves as a precursor to both THC and CBD, meaning that it is the first compound formed during the synthesis of the other cannabinoids. Unlike THC, CBG is non-psychoactive, meaning it does not produce the intoxicating effects commonly associated with cannabis use. This makes CBG an intriguing option for those seeking the potential benefits of cannabis without the mind-altering consequences.

How Does CBG Work? 

To understand how CBG works, it is important to explore the interactions between CBG and the body's endocannabinoid system (ECS). The ECS is a complex network of receptors, enzymes, and endocannabinoids that plays a crucial role in regulating various physiological processes and maintaining balance, or homeostasis, within the body.

CBG interacts with the ECS primarily by binding to cannabinoid receptors, specifically CB1 and CB2 receptors. CBG's interaction with these receptors is believed to modulate the activity of the ECS and influence various physiological functions, including mood, sleep, pain, and more.


What is CBG?

Origin Of CBG

CBG was first discovered in 1964 by scientists Yehiel Gaoni and Raphael Mechoulam. CBG, like other cannabinoids, is biosynthesized within the trichomes of the cannabis plant. Trichomes are tiny, hair-like structures that appear as glandular outgrowths on the surface of the plant, primarily on the flowers and leaves. They contain a rich reservoir of cannabinoids, terpenes, and other compounds.

During the early stages of the cannabis plant's growth, CBG is one of the primary cannabinoids produced (CBGA). As the plant matures, enzymes convert CBG into other cannabinoids, such as THC (tetrahydrocannabinol), CBD (cannabidiol), and CBC (cannabichromene). 

Benefits Of CBG

While research on CBG is still in its early stages, preliminary studies suggest that it may offer several potential health benefits. Some of the health conditions that CBG may potentially improve include:

  • Inflammatory Bowel Disease: CBG is believed to be a powerful anti-inflammatory agent, which could be beneficial in treating a variety of conditions. Studies have shown that CBG could have beneficial effects on inflammatory bowel disease. (1)
  • Antibacterial Properties. In a notable study conducted in 2008, CBG exhibited promising antimicrobial properties, specifically in combating methicillin-resistant Staphylococcus aureus (MRSA) bacteria. MRSA is known for causing drug-resistant staph infections that can be challenging to treat and pose significant health risks. (2) 
  • Helping with Glaucoma: Medical cannabis looks to be an effective treatment for glaucoma, and CBG may play a role in this. In a study published in 2008, it was suggested that CBG could potentially be an effective treatment for glaucoma due to its ability to reduce intraocular pressure. (3)
  • Helping with Huntington’s Disease: According to a 2015 study conducted on mice with Huntington's disease, CBG exhibited potential neuroprotective properties. The study suggested that CBG might hold promise not only in treating Huntington's disease but also in addressing other neurodegenerative conditions. (4)

It is essential to note that while these potential benefits are promising, further research, clinical trials, and comprehensive studies are necessary to fully understand CBG's therapeutic potential and its precise mechanisms of action.

How To Use CBG?

While CBG is still being researched, there are various methods of consumption and utilization that offer avenues for exploring its potential therapeutic effects (although CBG’s production in younger plants makes it difficult to find products that contain solely CBG). Here is what you should know:

  • Oral Consumption: CBG can be taken orally in the form of tinctures, capsules, and edibles.
  • Smoking: Smoking CBG involves rolling the flower in a joint or pipe and inhaling the smoke. 
  • Topical Application: CBG can also be applied topically in the form of creams, lotions, and salves. When applied to the skin, CBG is absorbed through the skin and into the bloodstream. 

When To Use CBG?

Determining when to use CBG largely depends on your personal wellness goals and the potential benefits you are seeking. Here are some scenarios where CBG may be considered:

  • Symptom Management: CBG may be used when seeking relief from specific symptoms or conditions. For example, if you experience chronic pain or inflammation, CBG's potential analgesic and anti-inflammatory properties could be beneficial. 
  • Wellness Routine: Incorporating CBG into your daily wellness routine can be beneficial even if you don't have specific health concerns. Some individuals use CBG as a proactive measure to support overall well-being.
  • Supportive Therapies: CBG might be considered as an adjunct therapy to support overall health and potential symptom management.
  • Stress Management: CBG may offer potential benefits for stress reduction and relaxation.

CBG should not be seen as a magical cure-all or a one-size-fits-all solution. While it holds promise and potential benefits, it's essential to approach CBG with realistic expectations and consider it as part of a holistic approach to wellness. 

Recommended Dosage

When it comes to finding the right dosage for CBG, it is important to be aware that there is no one-size-fits-all answer. It is best to start with a low dosage and gradually increase it to find the optimal balance for your individual needs. 

When deciding on your dosage, there are multiple factors to take into account, including your body weight, metabolism, the potency and type of extract, and your tolerance. Additionally, your wellness goals play a crucial role in making this determination.

A dosage of 5-20mg per day may be ideal. It is important to note that the effects of CBG can vary depending on the individual and the specific product. And It is important to consult with your healthcare provider before taking any CBG products. 

What Is CBD?

CBD, short for cannabidiol, is a naturally occurring compound found in the cannabis plant. It is one of over 100 cannabinoids found in cannabis, alongside THC (tetrahydrocannabinol). CBD is one of the most abundant cannabinoids in the plant, and unlike THC, it does not produce any psychoactive effects. CBD is non-intoxicating, meaning it won’t get you high or impair your cognitive abilities.

How Does CBD Work?

CBD works by interacting with the body’s endocannabinoid system (ECS). The ECS is a network of receptors and neurotransmitters that regulate various body processes, including mood, appetite, pain, and inflammation. CBD binds to the receptors in the ECS and helps to regulate the body’s functions.

Origin Of CBD

CBD is derived from the cannabis plant. The cannabis plant is a genus of flowering plants that includes different species, such as Cannabis sativa, Cannabis indica, and Cannabis ruderalis. CBD is present in varying concentrations in these different cannabis species.

Cannabis has been used for thousands of years for various purposes, including medicinal and recreational uses. The use of cannabis as a medicine can be traced back to ancient civilizations in different parts of the world, such as China, India, and Egypt.

CBD itself was first isolated and identified in the 1940s by Roger Adams and his research team. CBD has been studied extensively and is now widely accepted as a therapeutic compound with a wide range of potential health benefits.

Benefits Of CBD

CBD is believed to interact with the body’s endocannabinoid system, which is responsible for regulating a variety of biological functions, including mood, appetite, and sleep. By interacting with this system, CBD may help to reduce inflammation and relieve pain. It may also help to reduce anxiety, improve sleep. and promote relaxation. CBD offers many of the same benefits listed above for CBG.

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How To Use CBD?

CBD can be used in a variety of ways, depending on your goals and preferences. Common methods of CBD consumption include:

  • Orally: CBD can be consumed orally in the form of tinctures, capsules, edibles, and other products. This is one of the most popular methods of taking CBD, as it is fast, convenient, and easy to dose. CBD can also be added to food or beverages, such as smoothies or coffee.
  • Sublingually: Sublingual consumption is an alternative way to consume CBD by placing it under the tongue. Similar to oral consumption, this method allows for CBD to be absorbed into the bloodstream. Sublingual consumption offers a quicker and more direct absorption, making it an excellent choice for individuals seeking fast-acting effects.
  • Topically: CBD can also be used topically in the form of lotions, salves, and other topical products. This is a great option for those looking to target specific areas of the body with CBD.


How to use CBD


When To Use CBD?

CBD can be used in various situations and for different purposes. Here are some common scenarios in which people may choose to use CBD:

  • Relief from daily discomfort
  • Anxiety and stress relief
  • Sleep aid
  • Inflammation and immune support
  • Epilepsy and seizure disorders (FDA-approved Epidiolex in specific cases)
  • Improve overall well-being

It is important to note that CBD is not intended to diagnose, treat, cure, or prevent any disease. Before taking either of these cannabinoids, it is important to consult with your doctor and discuss the potential risks and benefits.

Recommended Dosage

When it comes to dosage, it is essential to remember that everybody is different and will react differently to different amounts of CBD. CBD dosage recommendations vary depending on the individual, their body weight, and the severity of their symptoms. Generally, it is recommended to start with a low dose and increase it gradually until you find the optimal amount. The recommended daily dosage of CBD is between 5-20mg per day. 

Can I Take CBG & CBD Together?

Yes, it is possible to take CBG and CBD together. When taken together, these two cannabinoids can work together to create a synergistic effect, known as the entourage effect. This means that the combined effects of the two cannabinoids can be more powerful than when taken separately. It is also important to note that the effects of CBG and CBD can vary from person to person. 

Key Differences Of CBG Vs CBD

CBD and CBG are cannabinoids found in cannabis, but they differ in their prevalence and interactions with cannabinoid receptors. CBD is a prominent cannabinoid, while CBG is considered a minor cannabinoid. As a result, cannabis plants typically contain higher concentrations of CBD compared to CBG. (5) 

Additionally, CBG, unlike other cannabinoids, is known for its stimulating properties. In contrast, CBD can have a sedating effect, especially at higher doses, which makes it popular as a sleep aid. 

These cannabinoids offer complementary benefits, making them a perfect pair to enhance your well-being. While further research is required to fully understand the extent of their benefits, both CBD and CBG show promise as compounds with diverse potential uses.

CBD Vs CBG: Which One Is The Best For You?

The answer to this question depends on your individual needs and preferences. Both CBD and CBG have their own unique benefits, but they also have their own drawbacks. It's important to understand the differences between the two compounds to determine which one is the best for you. 

However, due to the higher demand and availability, CBD products tend to be more affordable compared to CBG products, which are typically more expensive due to the lower concentration of CBG in cannabis plants. CBD is likely the better fit for everyone given that it offers similar effects, is widely available, and is more well-researched and established. 

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Final Thoughts

CBG and CBD represent two remarkable cannabinoids with unique properties and therapeutic potential. While CBD has garnered significant attention and a wide range of applications, CBG is an emerging player. 

Both compounds offer exciting possibilities for medical treatments and deserve further exploration. As scientific understanding of these cannabinoids continues to expand, we can expect more discoveries and innovations that may revolutionize the field of cannabis-based medicine.

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What are the downsides of CBG?

CBG, like any other cannabinoid, has the potential to cause side effects. The most common side effects of CBG may include dry mouth, nausea, changes in appetite, and dizziness. It is also possible that CBG could interact with other medications. It is important to speak with a doctor before taking CBG if you are taking any medications.

Can you take CBG every day? 

Yes. Generally, regular CBG consumption is well tolerated, even at higher doses of concentrated cannabinoids, particularly for individuals with prior experience. However, if you are new to CBG, we advise starting with lower doses and gradually increasing the dosage and CBG concentrations based on your body's response.

How long does CBG last?

The effects of CBG can vary from person to person, as everyone's body is unique. Factors such as BMI (Body Mass Index) and metabolism also influence the duration of CBG in your system. With all of these considerations in mind, and speaking generally, you should expect the effects of CBG to last between two to six hours.

Does CBD or CBG lower blood pressure?

Both CBD and CBG have been shown to have a positive effect on blood pressure. However, more research is needed to determine the exact effects of CBD and CBG on blood pressure.

How quickly does CBG work?

When consumed orally, such as in the form of capsules or edibles, CBG needs to be digested and processed by the liver before it enters the bloodstream. This process can take some time, typically ranging from 30 minutes to a few hours, before the effects are felt. If CBG is taken sublingually, it enters the bloodstream more rapidly, resulting in a quicker onset of effects. 

Can CBG And CBD Be Bought Legally?

Yes, Hemp-derived CBD and CBG products are federally legal if they contain less than 0.3% THC. However, their legality may vary from state to state depending on the amount of THC contained within them, with most states following the federal guidelines. Make sure to check your state and local laws to ensure that you can legally order the products you want before you seek to integrate CBD or CBG into your routine. 


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  2. Appendino, G., Gibbons, S., Giana, A., Pagani, A., Grassi, G., Stavri, M., Smith, E., & Rahman, M. M. (2008). Antibacterial Cannabinoids from Cannabis sativa: A Structure−Activity Study. Journal of Natural Products, 71(8), 1427–1430. https://doi.org/10.1021/np8002673
  3. Nadolska, K., & Goś, R. (2008). [Possibilities of applying cannabinoids’ in the treatment of glaucoma]. Klinika Oczna, 110(7-9), 314–317. https://pubmed.ncbi.nlm.nih.gov/19112869/
  4. Valdeolivas, S., Navarrete, C., Cantarero, I., Bellido, M. L., Muñoz, E., & Sagredo, O. (2014). Neuroprotective Properties of Cannabigerol in Huntington’s Disease: Studies in R6/2 Mice and 3-Nitropropionate-lesioned Mice. Neurotherapeutics, 12(1), 185–199. https://doi.org/10.1007/s13311-014-0304-z
  5. Walsh, K. B., McKinney, A. E., & Holmes, A. E. (2021). Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.777804