man stretching arm and yawning while sitting on a brown leather sofa with a book on his lap

CBD with Melatonin Side Effects (An In-Depth Look)

Melatonin and CBD are a potent duo, often appearing together in sleep supplements where their respective benefits deliver superior sleep support. While many people report success with these soothing ingredients, it’s essential to consider potential CBD with melatonin side effects before trying them yourself.

The good news is that CBD and melatonin supplements are generally safe and well-tolerated. Many people take these supplements to improve their sleep quality or manage primary sleep disorders like insomnia.

One of the easiest ways to avoid safety risks is to ensure you’re sourcing CBD supplements from a reputable brand. Our FOCL products are an excellent example — every batch of FOCL sleep gummies undergoes rigorous third-party testing to ensure consistent dosing and verify the absence of harmful contaminants.

Are you ready to unlock a safe and restful sleep? Here’s a comprehensive look at the safety and potential side effects of CBD sleep gummies with melatonin.

What Are the Side Effects of CBD with Melatonin?

Most people don’t experience side effects when taking CBD with melatonin. In a 2023 study on the effectiveness and safety of CBD and melatonin, only 12% of participants reported side effects, none of which were considered severe. In this study, the most common side effects were:

  • Fatigue/grogginess
  • Headache
  • Upset stomach
  • Dry mouth
  • Nausea
  • Restless feeling
  • Vivid dreams

Notably, participants who took supplements containing both melatonin and CBD reported lower rates of grogginess than those taking melatonin alone. More research is needed in this area, but these results suggest that CBD could reduce the side effects of melatonin.

If you’re going to try melatonin, less is more. Experts recommend taking just 1 to 3 mg before bed. Higher doses don’t appear to offer additional sleep benefits but increase the risk of grogginess the next day.

Supplement format can also influence how strongly you experience side effects. When taking CBD oil with melatonin, side effects may be more noticeable than those of gummies or capsules. CBD oil is taken under the tongue, allowing for direct absorption into the bloodstream and leading to more rapid onset of potential side effects.

Is it Safe to Consume CBD with Melatonin?

A woman sitting and stretching in bed after waking up

Consuming CBD with melatonin is safe for most users. In the study mentioned above, researchers found that these two ingredients are very safe, whether taken alone or together.

As we mentioned, one of the main side effects of this combo is drowsiness and fatigue, which could impact your ability to perform daily activities safely. As long as you’re taking CBD with melatonin before bed, sleepiness should not be a problem — that’s the whole idea!

There’s also a hidden risk when buying supplements from unknown sources. Some manufacturers might not prioritize the quality of their ingredients, potentially including unwanted fillers, contaminants, or even incorrect dosages in their products.

To ensure safety and effectiveness, stick to reputable brands like FOCL that commit to third-party testing every batch of supplements.

Are Products with CBD and Melatonin Addictive?

CBD and melatonin are not known to be addictive or habit-forming, unlike prescription sleep aids, which can be addictive.

You won’t develop a tolerance or become physically dependent on CBD or melatonin, even when taking them every day for extended periods. Research shows that supplementation of melatonin does not interfere with the body’s natural production.

However, if you rely on sleep supplements every night, it is possible to become psychologically dependent on them. This dependence might make you feel anxious when falling asleep without your supplements. To minimize your reliance on sleep aids, consider incorporating healthy sleep practices into your evening routine, like avoiding screens before bed.

Which Drugs Should You Avoid Mixing with CBD and Melatonin?

close-up of a scientist pipetting samples into a tube in a laboratory

Many prescription drugs are broken down by enzymes in the liver. CBD may compete for these enzymes, affecting the levels of certain medications in the body. This competition can interfere with the effectiveness of these medications or increase the risk of side effects.

Researchers from Penn State College of Medicine identified 139 medications that may be affected by cannabinoids like CBD and THC. They narrowed this list to 57 medicines for which interactions could have dangerous results. This list of medications contains various drugs, including:

  • Warfarin, a blood thinner
  • Amiodarone, a heart medication
  • Levothyroxine, a thyroid medication
  • Clobazam, lamotrigine, and valproate, which are seizure medications.

Melatonin can also interact with certain medications, especially those that increase drowsiness. Some of these drugs include antidepressants, benzodiazepines, opiates, and medicines that lower blood pressure.

If you’re taking any prescription medications, it’s a good idea to talk to your doctor before adding CBD and melatonin supplements to your routine.

What Are the Potential Benefits of Combining CBD with Melatonin?

an alarm clock and three wooden dice in a grassy field

Melatonin and CBD act on the body differently. Combining these two compounds can do double duty for sleep quality, especially for people struggling with sleep disorders. Let’s explore how these compounds work and why they’re a match made in heaven.

Melatonin is a sleep hormone produced by the pineal gland in response to darkness, making you feel drowsy at night. Your melatonin levels increase throughout the evening until they reach a level high enough to promote sleep, and taking melatonin can help your body reach this point faster.

Melatonin works particularly well when your sleep cycle is out of whack. If you’re a night owl who tends to stay up late, melatonin can help you shift your sleep schedule earlier. It is also useful for overcoming jet lag when traveling.

Research shows that melatonin supplementation also reduces the time it takes to fall asleep among people with delayed sleep-wake phase disorder. This disorder affects the internal clock and delays melatonin production.

On the other hand, CBD is a cannabinoid from the hemp plant that reduces anxiety and promotes a state of calm. Taking CBD before bed is perfect for relaxing your mind and body so you can easily slip into deep sleep.

The 2023 study we mentioned earlier found positive results when combining CBD with melatonin for sleep. Participants experienced more significant improvements in their sleep quality and noted fewer sleep disturbances when taking melatonin and CBD together than when taking melatonin or CBD alone.

If you want to learn more about these two fascinating compounds, check out this article, which deep-dives into melatonin and CBD for sleep.

What Are Some CBD and Melatonin Product Options?

a woman sitting at the foot of the bed in her pajamas and taking a FOCL sleeping gummy

If you’re interested in trying CBD and melatonin for sleep, you have many supplements to choose from, including gummies, capsules, and oil tinctures.

We love CBD gummies because they’re convenient and tasty. You can even cut them into halves or quarters if you want to start with a lower dose of CBD.

We’ve put together this article to provide you with a comprehensive list of the best CBD sleep gummies with melatonin, so be sure to check it out for product recommendations. Or, if you’re looking for CBD sleep supplements without melatonin, you’ll find another great list of options here.

As we mentioned earlier, choosing products from reputable brands is important. Doing so will ensure your supplements are safe, reducing the risk of health complications or unwanted side effects. Some CBD brands that meet these standards of quality include FOCL, Chill Frog, Medterra, and Soul.

a jar of FOCL Deep Sleep Gummies against a blue background

If you’re looking for a good place to start exploring the benefits of CBD with melatonin, our FOCL Deep Sleep gummies are perfect. Here’s why:

High-quality ingredients: Our CBD gummies are made with organically-grown hemp and third-party tested to ensure consistent dosing and uncompromising safety.

Full-spectrum CBD: Deep Sleep gummies are made with full-spectrum CBD. This formulation means they contain all the sleep-friendly compounds naturally occurring in the hemp plant, including CBN and trace amounts of THC, which work synergistically with CBD to promote relaxation.

Low melatonin content: These gummies contain just a hint of melatonin (1 mg) to help you fall asleep quickly without causing morning drowsiness.

An independent sleep study even backs FOCL Deep Sleep gummies. Participants in the study gained, on average, 1 hour and 48 minutes of extra sleep a night and 87% of participants reported that Deep Sleep was the best sleep aid they’ve ever tried.

FOCL is confident you’ll be impressed by our gummies, so we offer a generous 60-day satisfaction guarantee — one of the longest trial periods in the CBD gummies marketplace. This window will give you ample time to experience the benefits of CBD with melatonin, completely risk-free.

Minimizing CBD with Melatonin Side Effects

Taking melatonin and CBD together is a safe way to enjoy the sleep-promoting benefits of both compounds. While being mindful of potential side effects is essential, these supplements are generally very safe.

Remember, side effects are rare — and when they occur, they’re most often mild and manageable. If you want to reduce your risk of side effects, consider starting with a lower dose than the amount recommended on your product label. Pay attention to how you feel and adjust your dosage gradually until you find the sweet spot for your sleep.

Our FOCL Deep Sleep gummies are the perfect introductory sleep gummies. They feature a low dose of melatonin unlikely to cause dizziness or grogginess. Delivering full-spectrum CBD packed with a harmony of calming cannabinoids, these are guaranteed to support your sleep. Head over to our product page to learn more!